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He shou wu is said to act as an adaptogen, building the body’s defenses against stress, and also to support the balance between yin and yang energies. High cholesterol 4. The roots of this plant have been used in traditional medicine for thousands of years. None of these or other uses of P. multiflorum have been validated via extensive human trials. In the tissue culture study, brain cells exposed to excessive levels of the activating neurotransmitter glutamate showed signs of oxidative damage and early death. Epub 2011 Nov 20. data of protective effects of commercially available Polygonum multiflorum extract (PME) in vivo on aging and life span are limited. Zhongguo Zhong Yao Za Zhi. In one 28-day murine trial, oral administration of an aqueous solution of P. multiflorum affected the synthesis rates of transfer proteins and bile acid. It contains the substance emodin, which is a laxative and also is thought to be a liver protective agent. This plant is also used to darken hair that has greyed prematurely. The toxic and protective effects of Polygonum multiflorum on normal and liver injured rats based on the symptom-based prescription theory. J Ethnopharmacol. People respond differently to diets and supplements because everyone has unique DNA. … More than 100 chemical compounds have been isolated from Fo-ti, and the most biologically relevant components have been determined to be from the families of stilbenes, quinones, flavonoids, and phospholipids. Note that each number in parentheses [1, 2, 3, etc.] Hyperlipidemia, hypercholesterolemia and hypertriglyceridemia are conditions of blood lipid imbalance. Lin L1, Ni B1, Lin H1, Zhang M1, Li X1, Yin X1, Qu C1, Ni J2. J Ethnopharmacol. Torachrysone-8-O-β-D-glucoside, a compound found in P. multiflorum, can significantly increase the number of dermal papilla cells which play a role in hair growth and hair fiber length [39]. Loose Stools . Our website services, content, and products are for informational purposes only. Research has shown Polygonum multiflorum to: By relaxing the heart muscle and circulatory vessels via endothelial vasorelaxation, P. multiflorum may help to naturally increase blood delivery throughout all the body’s systems. However, you shouldn’t interpret them as supportive of any health benefit. SelfDecode provides recommendations that are. Can Vitamin D Reduce the Likelihood of Cancer. Fo-Ti or He Shou Wu is considered a powerful longevity herb in the system of Chinese Medicine. In traditional medicine, Polygonum multiflorum is not associated with any serious or lasting side effects. The hepatotoxicity of the water extract is higher than that of the ethanol and acetone extracts of P. multiflorum. Strengthening of the immune system is one of the traditional Fo-ti uses. This is especially helpful to older people. P. multiflorum was administered orally. In some traditional medicine practices, Polygonum multiflorum extracts are used to reduce certain risk factors for of cardiovascular disease. In a study on mice, P. multiflorum extracts promoted hair growth by stimulating hair follicles [38]. This can help to stabilize cellular structures throughout the body and support general health and anti-aging efforts. (P. multiflorum) or Fallopia multiflora is officially listed in the Chinese Pharmacopoeia and is one of the most popular herbs in Chinese medicine [1]. Emodin blocked the binding of SARS coronavirus to human cells in test tubes [23]. Dermatological conditions like carbuncles, itching, skin eruptions and sores; Toning the blood and other vital humors (yellow bile, black bile, phlegm); Balancing lipid profiles in the cardiovascular system; Fortifying the bones, tendons and muscles. side effects from drugs; stress; After a month of treatment, P.Multiflorum was able to produce symptomatic improvement in both sexes. Anecdotally, general side effects include diarrhea, nausea, abdominal pain, and vomiting. 2012 Jan 6;139(1):287-93. doi: 10.1016/j.jep.2011.11.022. According to the Natural Medicines Comprehensive Database, oral usage is considered “possibly unsafe” for adults and children due to several reports of liver damage. Wang T, Wang JY, Zhou ZX, Jiang ZZ, Li YY, Zhang L, Zhang LY. Fo-ti has traditionally been used to treat patients suffering from baldness and hair loss throughout East Asia. ... K. Chan, in Side Effects of Drugs Annual, 2015. We do not aim to diagnose, treat, cure or prevent any illness or disease. An extensive search of 6 medical databases was performed up to June 2014. Fo-ti components showed inhibitory effects against various types of cancer cells in test tubes, but this doesn’t reveal much about their potential anticancer effects in living beings [2, 37, 2]. According to the available evidence, it can not be suggested as a complementary approach for cancer treatment or prevention. Warfarin (prescribed to prevent the formation of blood clots) may interact negatively with P. multiflorum resulting in bone marrow suppression [2]. Research shows that TSG acts similarly to Atorvastatin, a drug used to block the production of cholesterol. We believe that the most accurate information is found directly in the scientific source. In North America, it is called fo-ti. Most notably — although rare — t’s been linked to cases of liver damage. Polygonum multiflorum extract supplements are marketed for purposes including combating aging, restoring sexual vigor, enhancing cellular health, stimulating the adrenal glands, detoxifying the blood and improving endocrine functioning. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Joe Cohen is well-known for his work as a successful entrepreneur in the health field after he overcame his many health issues using a personalized regimen. Femur and tibia weights and lengths in the OVX control group were decreased. Epub 2015 Nov 10. Fo-ti is also used in TCM for other conditions, including:1 1. P. multiflorum may also be toxic to the kidneys (nephrotoxicity) and the lungs (pulmonary toxicity), particularly after long-term use. P. multiflorum may cause embryonic toxicity in mice and may affect embryonic development, suggesting that it may not be safe for pregnant women. The effect of PM extract on bone weight and length was evaluated. People use this natural herb for the following: Other uses include treatment for lymph node tuberculosis, insomnia, premature greying, lower back and knee weakness, dizziness, tinnitus, high blood pressure (hypertension), constipation, prostatitis and cancer. Hot water extract of Fo-ti prevented bone loss (osteopenia) in a study on menopausal mice [25]. Therefore, … They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. The kidneys are often referred to as “the root of vitality” in TCM, since they are involved in essential life processes, including supporting our metabolism, reproduction, blood clean… Some research suggests that long-term use of He Shou Wu can cause dangerous side effects. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. P. multiflorum and its extracts should be considered hepatotoxic; however, the plant is widely used in traditional Chinese medicine and Ayurvedic medicine for its rejuvenating and toning properties, to increase liver and kidney function, for treatment of cognitive di… as two sides of the same biological coin. Joe Cohen won the genetic lottery of bad genes. Fo-ti may have significant interactions with other drugs that are metabolized by the liver, anti-diabetes drugs, laxatives, and more. Botanisch hört das Gewächs auf den Namen Fallopia multiflora, in Asien wird es He Shou Wu genannt. Your email address will not be published. Han MN1, Lu JM1, Zhang GY1, Yu J1, Zhao RH1. It is known to induce laxative effects. Find out exactly which supplements he takes and what lifestyle changes Joe has made to maintain optimal health and prepare his body to fight off infections. Required fields are marked *. This site uses Akismet to reduce spam. Emodin protects microglia cells in the brain from inflammation through AMPK/Nrf2 activation [19]. In rats, TSG protected the heart from squeezing pressure around the abdomen [14]. Polygonum multiflorum seems to stimulate the adrenals and encourage hepatic and renal detoxification. This processed Fo-ti is said to prevent heart disease by not allowing plaque to form in the blood vessels. Medscape - Indication-specific dosing for he shou wu, polygonum multiflorum (fo-ti), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & … The toxicity of processed Fo-ti is lower than that of the crude herb and this may be associated with the decreased levels of some of the components after processing [7]. This website contains affiliate links and we receive a commission when you purchase products through those links on our partner websites. Extracts of Fo-ti prevented brain tissue damage following a stroke in one study on mice [32]. Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. Case reports and case series involving liver damage associated with HSW were included. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better. Extracts from this plant have not been studied extensively in clinical trials. Start slow and titrate up if ... Read More In a cell-based study, Fo-ti protected neuronal cells from the hippocampus against high glutamate toxicity [33]. Tinnitus The unprocessed root, kno… Yao Xue Xue Bao 2015; 50 : 973–9. Exhibits antioxidant & neuroprotective effects. Follow label instructions closely and self-monitor for any adverse effects. As a kid, he suffered from inflammation, brain fog, fatigue, digestive problems, anxiety, depression, and other issues that were poorly understood in both conventional and alternative medicine. If you are concerned about the risks of taking Polygonum multiflorum orally, it is best to speak to your doctor about safe dosage levels. This is based on anecdotal reports of its effectiveness, though there are no clinical research studies that have examined this. Emodin, a chemical found in Fo-ti, inhibits the enzyme that breaks down acetylcholine, which might contribute to its pro-cognitive effects [2]. Information is shared for educational purposes only. An herbal mixture containing Fo-ti significantly reduced LDL cholesterol and triglycerides in a study of 42 participants. : a review. Polygonum multiflorum contains more than one hundred different phytonutrient (plant chemical) compounds. Research on Polygonum multiflorum shows that it contains alkaloid compounds. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists. Research is ongoing to determine the therapeutic benefits of this herb. The processed root has been used to lower cholesterol levels in Traditional Chinese Medicine. Much more research is needed to evaluate the potential anticancer effects of Fo-ti. SelfDecode provides recommendations that are personalized based on YOUR genes to help you stay healthy and avoid infections from viruses like COVID-19! He shou wu is sometimes used as a stool softener. As with any single herbal remedy, though, he shou wu may have side effects of its own. is a clickable link to peer-reviewed scientific studies. However, the influence of PM on osteoporosis in animals is unclear. This review covers a to… It has been used for thousands of years to promote long life, nourish blood, strengthen bones, tendons and muscles as well as many other purposes. It is known to induce laxative effects. Required fields are marked *. TSG prevented atherosclerosis by reducing lipid levels in the blood and suppressing inflammation (via the MMP-2 and MMP-9 genes) in another study on rats [15]. No valid clinical evidence supports the use of Fo-ti for any of the conditions in this section. based on YOUR genes to help you stay healthy and avoid infections from viruses like COVID-19! Atherosclerosis 2. Hepatotoxicity and hepatoprotection of Polygonum multiflorum Thund. Polygonum multiflorum (PM), a traditional Chinese medicine, is used to treat various diseases including nonalcoholic fatty liver disease and hyperlipidemia.However, the influence of PM on osteoporosis in animals is unclear. Join SelfHacked today and start the journey of improving your life, Get the Regimen of A Top Biohacker Preparing His Body to Fight Coronavirus, Avoid Illness By Using the Best Supplements For Your Body. The leaves, root tuber, and rhizomes have been used as a tonic in the anti-aging formula while the stem has been used to alleviate insomnia, help with diabetes, stimulate the immune system, and more [3, 4]. Polygonum Multiflorum in Thai ใช้ในการรักษา การบาดเจ็บที่ตับ, โรคมะเร็ง, โรคเบาหวาน และอาการอื่นๆ Als eine der wichtigsten Pflanzen in der traditionellen chinesischen Kräuterkunde hat Fo-Ti unsere vollste Aufmerksamkeit verdient – und genau die wollen wir dem vielblütigen Knöterich, dem sogenannten Polygonum multiflorum, heute schenken. After receiving several reports of liver disorders, including jaundice and hepatitis, the UK Medicines and Healthcare products Regulatory Agency (MHRA) issued a warning about the risks of using Polygonum multiflorum, advising members of the public who experience symptoms of liver disorders while taking products that contain Polygonum multiflorum to see their doctor and to stop taking the product … Animal and Cellular Research (Lacking Evidence). Background: Polygonum Multiflorum Thunb(PMT) has multiple biological effects, such as anti-inflammatory, lipid-lowering, anti-aging and so on. Wang M1, Zhao R, Wang W, Mao X, Yu J. Lipid regulation effects of Polygoni Multiflori Radix, its processed products and its major substances on steatosis human liver cell line L02. The present study investigated the antiosteoporotic effect of PM on bone mass in ovariectomized (OVX) mice and its possible mechanism of action. Tetrahydroxystilbene glucoside from Fo-ti helped with memory deficit in mouse models of Alzheimer’s [10, 11]. In another Chinese study (166 participants), a combination of Korean ginseng and Fo-ti improved mild cognitive impairment [9]. Processing may decrease hepatotoxicity, but the evidence is mixed [3, 2]. In test tubes, a methanol extract of Fo-ti had an anti-inflammatory effect on the immune cells stimulated by bacterial toxins. 2015 Jan 15;159:158-83. doi: 10.1016/j.jep.2014.11.009. 2007 Feb;32(4):323-6. In a mouse model of asthma, researchers observed the ability of Fo-ti to reduce airway inflammation and constriction [24]. Overdose may cause Nausea, Vomiting, Diarrhea. It has also been shown to protect liver cells from damage by toxins including dry cleaning fluid. Mechanistic Studies on the Use of Polygonum multiflorum for the Treatment of Hair Graying.Biomed Res Int. The best-known toxicity of P. multiflorum is liver or hepatotoxicity. Gao X1, Hu YJ, Fu LC. This helps to decrease heart rate and displace more blood with each beat of the heart, which can also have benefits for sexual performance and erectile function. One alkaloid (2, 3, 5, 4′-tetrahydroxystilbene-2-O-beta-D-glucopyranoside (TSG)) in P. multiflorum is believed to induce restoring effects on brain cells, neurons and endocrine glands. Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb. Polygonum multiflorum can interact with certain medications and may be inappropriate for individuals with certain health conditions. Polygonum multiflorum is the botanic name for He Shou Wu or Fo Ti – an ancient herbal remedy used in Chinese medicine for anti-aging benefits. The present study investigated the antiosteoporotic effect of PM on bone mass in ovariectomized (OVX) mice and its possible mechanism of action. He or she would be able to generate better insight on the effects of the extract on your health profile. Read on to learn the potential uses and side effects of Fo-ti. In North America, it is commonly known as Fo-ti. Lin HW, Sun MX, Wang YH, et al. Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets. A plus sign next to the number “[1+, 2+, etc...]” means that the information is found within the full scientific study rather than the abstract. Its popular usage stems mainly from historical records of its use for low libido, suppressed immunity, cardiovascular inefficiency and as a laxative. Folks have used it to relieve insomnia, combat diabetes, stimulate hair growth, and more. Ever try supplements that don’t seem to work? Planta Med 2010;76(9):889-92. Align your health hacks with your genes for optimal health & cognitive function. Processing Fo-ti, as opposed to using the raw herb, influences the amount and type of chemical constituents found in the plant [5, 6]. 2015 Jun;40(11):2163-7. Because of this, its physiological effects and side effects are not well defined. No clinical evidence supports the use of Fo-ti for any of the conditions listed in this section. All of our content is written by scientists and people with a strong science background. In TCM and Asian herablism, he shou wu (pronounced huh show woo) is a popular and highly revered tonic herb. You should also speak to a doctor before combining this supplement with any prescription or over-the-counter medications. Jonathan Ritter, PharmD, PhD (Pharmacology), What Are Mitochondria? Below is a summary of up-to-date animal studies, cell-based research, or low-quality clinical trials which should spark further investigation. A Chinese clinical trial of 209 Alzheimer’s disease patients found significant benefits of Fo-ti extract for cognitive decline, but it lacked a placebo control [8]. Fatigue 3. Was sich dahinter verbirgt? Taking fo-ti along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Definition, Function & Structure, Causes of High Uric acid, Associated Problems + Ways to Decrease. Selfhacked LLC does not provide medical advice, diagnosis, or treatment. Epub 2014 Nov 18. Polygonum multiflorum is an herbaceous vining plant that is indigenous to central and south China. This alkaloid demonstrates regulating effects on blood lipids and is being explored for its cardioprotective benefits. Chinese Cornbind, Chinese Knotweed, Climbing Knotweed, Fallopia multiflora, Flowery Knotweed, Fo Ti Tieng, Fo-Ti, He Shou Wu, Ho Shou Wu, Multiflora Preparata, Polygonum, Polygonum Multiflorum, Polygonum,Polygonum Multiflorum Thunberg, Racine de Renouée Multiflora, Radix Polygoni Multiflori, Radix Polygoni Shen Min, Renouée, Renouée à Fleurs Nombreuses, Renouée de Chine, Renouée Multiflora, Reynoutria multiflora (Thunb), Rhizoma Polygonata, Shen Min, Shou Wu, Shou Wu Pian, Tuber Fleeceflower, Zhihe Shou Wu, Zi Shou Wu. Methods. Anti-HIV activities of the compounds isolated from Polygonum cuspidatum and Polygonum multiflorum. When taken by mouth: Fo-ti is POSSIBLY UNSAFE to take by mouth due to concerns that it might cause liver damage in both adults and children. Polygonum multiflorum has been linked to liver complications. In another study, 507 subjects were observed. Side Effects, Risk Factors of, and Cautions for Polygonatum Avoid in case of Pregnancy and Breastfeeding. Make sure to consult your doctor before supplementing [45, 46, 47]. The most common side effect is weird dreams and being too groggy the next day. It inhibited NF-kB activation and thus reduced nitric oxide, COX-2 enzyme, and inflammatory cytokines like TNF-alpha and IL-6 [18]. Avoid the use if debilitated with Phlegm, Stomach, and Spleen Disorders. Learn how your comment data is processed. Other minor and temporary side effects may include bloating, flatulence, nausea and diarrhea. Fo-ti, together with red ginseng, helped with metabolic syndrome in a study on rats by improving [34]: Scientists observed the potential of emodin from Fo-ti to suppress the growth of colon and gallbladder cancer in mice [35, 36]. They are associated with the development of arterial plaque which can cause atherosclerosis. However, there is very limited research into the safety of this supplement. At the same time it may also reduce cholesterol in the blood and the liver due to the presence of chemicals called lectins, which prevent fat accumulating in the blood. Medications that are metabolized by the liver follicles [ 38 ] to complications. Into CAD ( coronary artery disease ) which is the root boiled in a cell-based [... Diagnosis, or low-quality clinical trials which should spark further investigation to bridge the gap between science and everyday,. Spectrum of pharmacological effects, including anti-aging, immunologic, neuroprotective, anticancer and anti-inflammatory effects any given.. Help to reduce the effects of its bioactive compounds, et al thymus and splenic in... Dismutase, P. multiflorum extracts are used to lower cholesterol levels in traditional medicine practices Polygonum! Multiflorum seems to stimulate the adrenals and encourage hepatic and renal detoxification cholesterol levels traditional. 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